| abstract |
NEW MATERIAL:Syn form carboxylic acids expressed by formula I [R 1 is formula IV (Ra is amino, protected amino; X is halogen), formula V or formula VI; R 2 is carboxy or protected product of carboxy-substituted lower alkyl] and salt thereof. n EXAMPLE: 2-(4-Aminopyrimidine-2-yl)-2-tert. butoxycarbonylmethoxyiminoacetic acid. n USE: A medicine. a synthesizing intermediate of novel 7-substituted 3-cephem-4- carboxylic acid expressed by formula VII (R 4 =R 2 ) having excellent antimicrobial activity to wide pathogenic germs containing Gram-negative and Gram-positive bacteria and useful as an antibiotic. n PREPARATION: A compound expressed by formula II or salt thereof is reacted with a compound expressed by formula III or salt thereof in a solvent, preferably in the presence of an organic or inorganic base normally while cooling or heating to provided the compound expressed by formula I. n COPYRIGHT: (C)1988,JPO&Japio |