| abstract |
NEW MATERIAL:A compound shown by formula I (R 1 is H, lower alkyl or lower alkanoyl; R 2 is H or halogen) and a salt thereof. n EXAMPLE: 1-Cyclopropyl-6-fluoro-7-(1-homopiperazinyl)-1,4-dihydro-4-oxoquinoline- 3-carboxylic acid.hydrochloride. n USE: An antimicrobial agent. n PREPARATION: A 7-halogenoquinoline-3-carboxylic acid derivative (e.g. 7-chloro-1- cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, etc.) shown by formula II (X is halogen) is reacted with a homopiperazine derivative shown by formula III optionally in a solvent such as pyridine, etc., at room temperature W 200°C. n COPYRIGHT: (C)1988,JPO&Japio |