http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S63126862-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a452aeb7f766d55db6921d784361b891 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 |
| filingDate | 1987-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0abb2ae570c95c4c3eec731487fe8900 |
| publicationDate | 1988-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S63126862-A |
| titleOfInvention | Production of 1alpha-hydroxyvitamin d2 |
| abstract | PURPOSE: To readily obtain the titled compound in high yield, by passing through a novel intermediate ergosta-1,5,7,22-tetraen-3β-ol to provide 1α-hydroxy- ergosteryl diacetate and subjecting the resultant diacetate to irradiation with light, etc. n CONSTITUTION: Ergosta-1,4,6,22-tetra-3-ene expressed by formula I is reacted with isopropenyl acetate and the resultant product is subjected to reductive reaction to provide a novel intermediate expressed by formula II, which is reacted with 4-phenyl-1,2,4-triazoline-3,5-dione to afford a Diels-Alder type addition reaction product expressed by formula III. The resultant compound expressed by formula III is subjected to protection of OH group, epoxidation, deprotection and converted into a compound expressed by formula IV, which is then reduced and acetylated to give a compound expressed by formula V. The epoxy group is subsequently converted into ethylene group to afford a diacetate expressed by formula VI, which is then subjected to irradiation with light to provide 1α,3β-diacetoxyprevitamin D 2 . The obtained compound is further subjected to thermal isomerization and deacetylation reactions to give the aimed compound. n COPYRIGHT: (C)1988,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5157135-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004504295-A |
| priorityDate | 1987-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.