| abstract |
PURPOSE: To obtain the titled composition consisting of a polypeptide, an ascorbic acid as an absorption promoter and a water-absorbing solid base suitable for nasal mucosa. n CONSTITUTION: A powdery composition for nasotracheal administration containing a physiologically active polypeptide (e.g. peptide hormone such as calcitonin, physiologically active protein such as interferon; enzyme protein such as lysozyme, etc., vaccine such as influenza vaccine, etc.), an ascorbic acid (e.g. ascorbic acid, erysorbic acid, etc.) as an absorption promoter and a water-absorbing solid base (e.g. water-absorbing and slightly water-soluble cellulose, starch, protein, crosslinked vinyl polymer or gum) suitable for application to nasal mucosa. The concentration of the ascorbic acid is preferably 0.1W30wt% based on sum of the composition. The composition can be made into powder in unit administration form and can be packed into capsules as preferable form. n COPYRIGHT: (C)1988,JPO&Japio |