| abstract |
NEW MATERIAL:A compound of formula I [R 1 and R 2 are H, lower alkyl, cycloalkyl, mono- or di(lower alkyl)amino, amino, aryl, etc.; Y 1 and Y 2 and H, lower alkyl, halogen or trihalogenomethyl; Z is carboxyl, lower alkoxycarbonyl, tetrazolyl, OH, etc.; n is 1W6; dotted line is single or double bond]. n EXAMPLE: {[5-Chloro-3-(2-methylphenyl)-4-oxo-4H-1-benzopyran-7-yl]oxy }acetic acid. n USE: Pharmaceuticals having excellent uric acid secreting action, diuretic action and hypotensize action. n PREPARATION: A compound of formula I wherein the dotted line is double bond and Z is R 5 can be produced by reacting a compound of formula II with a compound of formula III (Q is halogen; R 5 is lower alkoxycarbonyl or OH) in an organic solvent such as acetone in the presence of an alkali metal or alkaline earth metal carbonate (e.g. K 2 (O 3 ), etc. n COPYRIGHT: (C)1988,JPO&Japio |