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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22
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filingDate 1986-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35e090d33a3b37ff7d8fb39d89db53fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebf7dcbd309b1f8181f7c1838f2b7f58
publicationDate 1988-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S63104983-A
titleOfInvention Production of 7-aminodesacetoxy-cephalosporanic acid esters thereof
abstract PURPOSE: To obtain the titled compound as an intermediate for an antibacterial agent, by reacting esters of 7-acylamidedesacetoxycephalosporanic acid with an imino halide-forming agent in the presence of an aniline homologue, followed by reaction with a lower alcohol and hydrolysis thereof. n CONSTITUTION: Esters of 7-acylamidedesacetoxycephalosporanic acid expressed by formula I (R 1 represents phenyl-acetyl or pyhenyloxyacetyl; -COOR 2 represents esterified carboxyl) are reacted with an imino halide-forming agent (preferably phosphorus oxychloride, etc.) in an inert solvent (preferably methylene chloride, chloroform, etc.) in the presence of an aniline homologue (example; dimethylaniline, etc.). Then the product is reacted with a 1W7C alcohol and subjected to hydrolysis within an acidic region (example; pH=1) to give the aimed compound expressed by formula II. n COPYRIGHT: (C)1988,JPO&Japio
priorityDate 1986-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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