| abstract |
NEW MATERIAL:A compound expressed by formula I (R 1 is H or lower alkyl; R 2 is H, lower alkyl or acyl which may be substituted by halogen; R 3 is halogen, lower alkyl or lower alkoxy) and salt thereof. n EXAMPLE: cis-3-Acetylaminomethyl-4-chloropyrrolidine. n USE: An intermediate for producing pyridonecarboxylic acid derivatives having antimicrobial activity. n PREPARATION: A compound expressed by formula II (Z is -CH 2 N 3 or -CN) or formula III (R' 2 is acyl group) is reduced in the presence of a reducing agent, e.g. Pd-C or Raney Ni, in a solvent, e.g. THF or methanol, at 0W80°C for 30 minW24hr while stirring. If R is a protecting group, it is removed from the resultant reaction product to afford the aimed compound expressed by formula I. n COPYRIGHT: (C)1987,JPO&Japio |