| abstract |
NEW MATERIAL:The titled compound which is a compound expressed by formu la I [R 2 and R 3 are H, hydrocarbonsilyl or group together with O of OH form acetal bond; R 4 is H, methyl or vinyl; R 5 is alkyl which may contain O, phenyl, phenoxy, cycloalkyl, alkoxy or alkyl (substituted by phenyl, phenoxy, etc.); n is 0 or 1; X is O or H(OR 1 ) (R 1 is H, trihydrocarbonsilyl, acyl, hydro carbonsulfonyl, etc.] and an enantiomer or a mixture thereof in an optional proportion. n EXAMPLE: [1S, 5S, 6S, 7R]-2-Oxo-3-methylene-6-[(E,3S)-3-hydroxy-1-octenyl]-7-hy drobicyclo[3.3.0]octane. n USE: A key sythetic intermediate for isocarbacyclin. n PREPARATION: For example, a compound expressed by formula II (R 21 and R 31 are R 2 and R 3 other than H) is oxidized to afford the aimed compound expressed by formula I (X is O). n COPYRIGHT: (C)1987,JPO&Japio |