| abstract |
NEW MATERIAL:A nitrogen-containing tetracyclic compound expressed by formula I [R 1 and R 2 are lower alkyl; R 3 is H, lower alkyl, lower alkoxy or hydroxyl; (n) is integer 1W3]. n EXAMPLE: 5,10-Dihydro-2-hydroxy-1,3-dimethylindeno[1,2-b]indole. n USE: Useful as an antiasthmatic agent, antiallergic agent (prevention and treatment of allergic dermatitis, allergic rhinitis, urticaria, etc.), anhtirheumatic agent, antithrombotic agent, remedy for arteriosclerosis, etc., and capable of exhibiting improved inhibitory action on lipoxygenase of a polyfunctional unsaturated fatty acid by oral addministration. n PREPARATION: A phenylhydrazine compound expressed by formula II is reacted with a compound expressed by formula III (R 4 is H, lower alkyl, etc.) to give a compound expressed by formula IV, which is then cyclized to afford a compound expressed by formula V. When R 4 is lower alkyl, it is eliminated to give the aimed compound expressed by formula I. n COPYRIGHT: (C)1987,JPO&Japio |