| abstract |
NEW MATERIAL:A compound expressed by formula I [R 1 is H, (OH, lower alkoxy, amino, etc.-substituted) lower alkyl; R 2 is H, amino or lower alkylamino; R 3 is lower alkyl] and a nontoxic salt thereof. n EXAMPLE: Ethyl 2,6-bis(N-methylcarbamoyl)pyridine-4-carboxylate. n USE: A medicine, having antiallergic action and useful as a remedy for asthma, pollinosis, atopic dermatitis, etc. n PREPARATION: A compound expressed by formula I (R 1 ' is a group after removing H from R 1 ) is amidated with 2W20mol lower alkylamine expressed by the formula R 3 NH 2 in a solvent, e.g. tetrahydrofuran, at 0W50°C to give a compound expressed by formula I (R 1 is R 1 '), which is then hydrolyzed to give the compound expressed by formula I (R 1 is H). n COPYRIGHT: (C)1987,JPO&Japio |