http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6248694-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb75b0b19820e3833ebdcb31603b242b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-38 |
| filingDate | 1985-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8e93333c4cc83aec099de37ee0aee29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e164aa3d06ee0362d1686c729ca74f5 |
| publicationDate | 1987-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6248694-A |
| titleOfInvention | Antialdosterone active steroid derivative |
| abstract | NEW MATERIAL:A compound expressed by formula I (X is H or, together with Y, forms methylene; Y is H, alkanoylthio or aroylthio when X is H; the broken lines at C 1 -C 2 and C 6 -C 7 are, as necessary, double bond). n EXAMPLE: 17-Hydroxy-15β, 16β-methylene-3-oxo-17α-pregna-4, 11-diene-21-carboxy lic acid.γ-lactone. n USE: A hypotensive and diuretic agent, diagnostic agent, remedy for aldosteronism, etc. n PREPARATION: For example, the 16α-position of suitably protected 17- ethylenedioxy-3β-hydroxyandrosta-5,11-diene is halogenated to give a compound expressed by formula II (R is acyl, etc.), which is then dehydrohalogenated to form a double bond. β-Methylene group is then introduced into the double bond, and further ethynyl group is introduced into the ketone at the 17-position to afford a compound expressed by formula III, which is then converted into a hydroxy.carboxylic acid. The resultant hydroxy.carboxylic acid is dehydrated and cyclized, and the OH group at the 3-position is oxidized to give the aimed compound expressed by formula I (X and Y are H; the broken lines are not double bond). n COPYRIGHT: (C)1987,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006516249-A |
| priorityDate | 1985-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.