| abstract |
NEW MATERIAL:An oxazoleacetamide derivative expressed by formula I (X is H or halogen; R is substituted amino). EXAMPLE:2-(4-Chlorophenyl)-5-methyl-4-morpholinocarbonylmethyloxazole. USE:A medicine, exhibiting remarkable pharmacological action even on oral administration, having type I and type III antiallergic action, antiinflammatory action and further antiSRS-A (antislow-reacting substance of anaphylaxis) and useful as a preventing and treating agent for autoimmune diseases, e.g. asthma, rheumarthritis, nephritis, cancer, etc. PREPARATION:A compound expressed by formula II is treated with a halogenating agent to give a compound expressed by formula III, which is then reacted with a compound expressed by the formula RH in the presence of an organic base in an inert solvent or the compound expressed by formula II is reacted with the compound expressed by the formula RH in the presence of a dehydrating agent in an inert solvent to give the aimed compound expressed by formula I in good yield. |