| abstract |
NEW MATERIAL:A compound expressed by formula I [R<1> is formula II (A<1> and A<2> are C or N; R<3> and R<4> are H, hydroxyl group, lower alkoxy, amino, etc.), formula III (A<3> is O, S or NH), etc.; n is an integer 1-5; R<5> and R<6> are H, hydroxyl group or lower alkoxy] and a salt thereof. EXAMPLE:2-(Piperonylthio)benzodioxazole. USE:A medicine and compound useful for preventing and treating hepatopathy. PREPARATION:A thiol compound expressed by the formula R<1>-SM (M is H or alkali metal) or a thiolate compound which is an alkali metal substitution product thereof is reacted with a (substituted) benzodioxazolyl lower alkyl halide or sulfonate expressed by formula IV (X<1> is halogen or lower alkylsulfonyloxy, etc.) to afford the aimed compound expressed by formula I. |