| abstract |
NEW MATERIAL:The benzoquinone derivative of formula I (l is 0W18; X is H, alkyl or carboxylic acid acyl; Y is phenylene, cycloalkylene or group of formula II; m is 0W3; R 1 and R 2 are alkyl). n EXAMPLE: 6-( 10-Hydroxy-10-methylundecyl )-2,3-dimethoxy-5-methyl-1,4-benzo quinone. n USE: Useful as a remedy for circulatory disorder and antiallergic agent. It exhibits the electron transfer action in the succinic acid oxidase system of mitochondrion and the activity to activate the energy methabolism of a cell. It is also effective to suppress the formation of NADPH and Fe ++ -dependent lipid peroxide in the liver and brain. The agent has low toxicity and retains drug action for a long period. n PREPARATION: The compound of formula IV which is one of the compound of formula I can be produced e.g. by oxidizing the compound of formula III (Z is H or OH) with an oxidizing agent such as hydrogen peroxide. n COPYRIGHT: (C)1987,JPO&Japio |