| abstract |
NEW MATERIAL:A phenylmethylbenzoquinone derivative of formula I [R 1 , R 2 and R 3 are independently H, methyl or methoxy; A is ethylene or vinylene; n is 0 or 1; R 4 is H, hydroxymethyl or (esterified or amidated) carboxyl]. n EXAMPLE: 3-[3-(2,5-Benzoquinonylmethyl)phenyl]acrylic acid ethyl ester. n USE: It has brain-protective action in cerebral anoxia and is useful as an ameliorating and remedying agent for intracerebral organic disorder and pathergasia. n PREPARATION: The compound of formula I can be produced e.g. by reacting an aldehyde of formula II with a Grignard reagent of a halide of formula III [X is Br or Cl; R 7 is group of formula IV or -CH(OC 2 H 5 ) 2 ], treating the product with an acid, reacting with Wittig reagent of triethyl phosphonoacetate and subjecting the product to reaction with acetic anhydride, catalytic reduction, hydrolysis, etc. n COPYRIGHT: (C)1987,JPO&Japio |