| abstract |
NEW MATERIAL:A compound of formula I [R is H or alkyl; R<1> is alkyl; R<2> is H, halogen, NH2 or NO2; X is halogen; Z is halogen, group of formula II (n is 1 or 2; R<3> is H, alkyl, acyl, alkoxycarbonyl, etc.; R<4> and R<5> are H, alkyl, phenyl, etc.), azetidino, pyrrolidino, 3-hydroxypyrrolidino, morpholino, etc.], its salt and their hydrate. EXAMPLE:1-Cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-4-oxo-7-(1-piperazinyl)-3- quinolinecarboxylic acid. USE:An antibacterial agent having high activity against Gram-positive bacteria as well as aerobic Gram-negative bacteria and exhibiting strong activity also to anaerobic bacteria and mycoplasma, etc. PREPARATION:A compound of formula I wherein Z is Z<1> can be produced by condensing the compound of formula III with an amine of formula Z<1>H (Z<1> is Z excluding halogen). |