http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S62244394-A

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filingDate 1986-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b068698ddee8d1da50e6a37184d77170
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publicationDate 1987-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S62244394-A
titleOfInvention Biochemical production of optically active 4-hydroxy-2-cyclopentenone
abstract PURPOSE: To obtain the titled cyclopentenone useful for antiulcer action, thrombolytic action, etc., at a low cost in simple equipment, by reacting an ester of a specific compound with an esterase derived from a microorganism of the genus Achromobacter, etc. n CONSTITUTION: A microorganism, e.g. the genus Achromobacter or Candida, capable of asymmetrically hydrolyzing an organic carboxylic acid ester of a racemic 4-hydroxy-2-cyclopentenone expressed by the formula (R is 1W18C alkyl, 2W18C alkenyl or 2W18C alkenyl) and producing optically active 4- hydroxy-2-cyclopentenone is cultivated to give a culture. The resultant culture, etc., is then added to a 0.1W5wt% solution of the above-mentioned racemic cyclopentenone ester to carry out asymmetric hydrolysis reaction at 10W70°C and 6W10 pH within 10hr and the reaction solution is then subjected to treatment, e.g. fractional distillation, etc., to separate and recover the aimed optically active 4-hydroxy-2-cyclopentenone. n COPYRIGHT: (C)1987,JPO&Japio
priorityDate 1986-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 22.