| abstract |
NEW MATERIAL:A quinolone derivative of formula I [X1 and X2 are H or halogen; Y is O or S; R1 is H, lower alkyl or benzyl; R2 is halogen, lower mono- or dialkylamino, group of formula II or formula III (Z is O, S or R8-N; R4-R6 and R8 are H or lower alkyl; R7 is H, hydroxyl, amino, lower mono- or dialkylamino, etc.); R3 is lower alkyl, lower alkenyl etc.; n is 3-5], its ester and salt. EXAMPLE:5-Benzyloxy-1-cyclopropyl-6, 7, 8-trifluoro-1,4-dihydro-4- oxoquinoline-3- carboxylic acid ethyl ester. USE:Useful as an antibacterial agent. Also useful as a drug for man and animal, drug for fish disease, agricultural chemical, food preservative, etc. PREPARATION:The compound of formula I can be produced e.g. by reacting a novel compound of formula IV (X3 is halogen) with a compound of formula V in the presence of a base. |