| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f417c659231b7daa2dd729da2517636 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate |
1986-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_904ecad73e9ae3ecefd4cafbee32a45c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72ec2e1e5b3fd89743ae3ef6e8c40e2b |
| publicationDate |
1987-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-S62226926-A |
| titleOfInvention |
Long acting complex granule |
| abstract |
PURPOSE: The titled complex granule having high durability, obtained by combining slow-acting granules which have an intermediate layer consisting of a substance to prevent a drug from transferring to the outside and a layer made of an enteric coated substance with rapid-acting granules. n CONSTITUTION: Long acting complex granules consisting of slow-acting granules obtained by providing the surface of granules containing one or more of pyridonecarboxylic acid antibacterial agent (e.g. norfloxacin) or cephem antibiotic (e.g. cephalexin) as a drug with an intermediate layer comprising a substance (e.g. amino acid, protein or saccharide) to prevent the drug from transferring to the outside as a main constituent unit and forming a layer comprising an enteric coated substance (e.g. cellulose acetate phthalate) as a main constituent component on the intermediate layer and rapid-acting granules. The formation of the intermediate layer in the slow-cating granules makes elution of the drug in a first solution hard and causes no migration of the drug to the surface in the interior of the granules even by long-term preservation. n COPYRIGHT: (C)1987,JPO&Japio |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11779547-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2454955-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6586012-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9707260-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9717696-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016517867-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9572782-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H09510709-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6482823-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10420730-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0103698-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9386802-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11207273-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008535922-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9668982-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11207276-B2 |
| priorityDate |
1986-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |