| abstract |
NEW MATERIAL:A compound shown by formula I [X is single bond, CHR 4 -CHR 5 (R 4 and R 5 are H or alkyl), trans CR 4 =CR 5 or C≡C; R 1 is H, alkyl, OH or phenyl; R 2 is COOH, 1H-tetrazol-5-yl, SO 3 H, group shown by formula II (Y is 0 or S: m is 1W4), etc.; R 3 is H, halogen, alkyl, etc.; group shown by formula III is cis CH=CH or C≡C; n is 6W8] or a salt thereof. n EXAMPLE: (2E,11Z,14Z)-N-(3-Carboxyphenyl)-eicosa-2,1,1,14-trieneamide. n USE: A 5-lipoxygenase inhibitor. n PREPARATION: For example, a compound shown by formula IV and a compound shown by formula V (R 2a is R except group shown by formula II) are subjected to amide bond-forming reaction to give a compound shown by formula I. n COPYRIGHT: (C)1987,JPO&Japio |