| abstract |
NEW MATERIAL:The compound of formula I {X and Y are =N-OR 3 [R 3 is H or lower alkyl (substituted with cyano, lower alkoxy, halogen, aryl, etc.)] or one of X and Y is =N-OR 3 and the other is O; R 1 is H, OH or mycarosyl of formula II; R 2 is H or mucinosyl of formula III} or its salt. n EXAMPLE: 4'-Deoxy-9-deoxo-9-ethylhydroxyiminomicaminoxyltylonolide. n USE: Antibacterial agent exhibiting excellent phylactic effect. n PREPARATION: A tylosin derivative of formula IV [A is (protected) aldehyde group; B is (protected) carbonyl] is made to react with (substituted) hydroxylamine of formula H 2 N-OR 3 and, if necessary, the protecting group is removed from the product. n COPYRIGHT: (C)1987,JPO&Japio |