| abstract |
NEW MATERIAL:A compound shown by formula I [R 1 WR 4 are H, lower alkyl, haloalkyl, alkenyl or any two substituent groups of R 1 WR 4 are bonded to form ring; X is CH 2 , O, S(O) p (p is 0W2) or NR 5 (R 5 is H, lower alkyl, etc.); Y is O, S(O) q (q is 0W2), etc.; Z is (substituted) piperazino, homopiperazino, azetidino, pyrrolidino, etc.,; l, m and n are 0 or 1; R is H, lower alkyl or substituted boron], a salt or a hydrate thereof. n EXAMPLE: 9,10-Difluoro-2,3-dihydro-7-oxo-7H-pyrido[1,2,3-d,e]spiro[1,4-benzoxa zine-3,1'-cyclopropane]-6-carboxylic acid ethyl ester. n USE: An antibacterial agent. n PREPARATION: A compound shown by formula II (Hal is halogen) is reacted with an amine shown by formula Z'-H [Z' is (substituted) piperazino, etc.,]. n COPYRIGHT: (C)1987,JPO&Japio |