| abstract |
NEW MATERIAL:An acylamino acid derivative of formula I (n is integer of 0W6; R 1 is 5W25C saturated or unsaturated fatty acid residue; R 2 is H; R 3 is H, 3W5C branched alkyl, phenyl, hydroxyphenyl, aralkyloxyphenyl, indolyl, imidazolyl, methylthio or R 2 and R 3 together form a bond between C and N). n EXAMPLE: N-Oleoyl-L-phenylalanylpyrrolidine. n USE: A prolylendopeptitase-activity inhibitor effective in improving and curing symptoms of psychic function caused by cerebral organic disorder, especially amnesia. n PREPARATION: The compound of formula I can be produced by reacting a compound of formula R 1 -A or R 1 -O-R 1 (A is OH or halogen) with a compound of formula II in the presence of a base preferably trialkylamine or pyridine base. n COPYRIGHT: (C)1987,JPO&Japio |