| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_692dc75829481c48c017b52f352e2bad |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-42 |
| filingDate |
1986-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c3b0769e96a6cb621f95660afa57ab6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1aaf45e14bcfc22589c7bebde7f78fb |
| publicationDate |
1987-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-S62178521-A |
| titleOfInvention |
Liposome containing hemoglobin |
| abstract |
PURPOSE: To obtain the titled liposome active to prevent oxidation of hemoglobin and useful as an artificial erythrocyte, by including an aqueous solution of hemoglobin containing vitamin C in a liposome having vitamin E-containing membrane composed of a lipid. n CONSTITUTION: The objective hemoglobin-containing liposome is produced by including an aqueous solution of hemoglobin in a liposome having membrane composed of a lipid, wherein said membrane contains vitamin E and said hemoglobin solution contains vitamin C. Oxidation of hemoglobin in said liposome can be prevented by the vitamin C existing in the aqueous solution of hemoglobin and oxidation of the membrane is prevented by the vitamin E present in the membrane wall of liposome. Accordingly, there is no lowering of oxygen- transfer capability. The amount of vitamin E is 0.5W4.5mol% of total lipid and that of vitamin C is 2W10mol per 1mol of hemoglobin. n COPYRIGHT: (C)1987,JPO&Japio |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-5046327-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0980202-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0673241-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2712190-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H02501826-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6764693-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0466456-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1449522-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6461426-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0615747-A1 |
| priorityDate |
1986-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |