| abstract |
NEW MATERIAL:The compound of formula I [R 1 is amino or protected amino; R 2 is H, OH-protecting group, (dihalogenated) lower alkyl, lower cycloalkyl, thiethanyl, etc.; R 3 is lower alkyl; R 4 and R 5 are H, lower (hydroxy) alkyl, lower alkoxy, amino, etc.; R 6 is COO - , COOH or protected COOH; X - is anion; n is 0 or 1; when R 2 is lower carboxyalkyl, then R 4 is H and R 5 is amino; when R 6 is COO - , n is 0, etc.]. n EXAMPLE: 7β-[2-(2-Aminothiazol-4-yl)-2-(difluoromethoximino)-acetamido]-3-(2-me thyl-1-pyrazolio) methyl-3-cephem-4-carboxylate. n USE: Antibacterial agent against Gram-positive bacteria, Gram-negative bacteria, etc. n PREPARATION: The compound of formula II is made to react with the compound of formula III. n COPYRIGHT: (C)1987,JPO&Japio |