| abstract |
PURPOSE: To produce the titled slow-releasing drug preparation, by adding a drug such as growth regulator, osteometabolism-relating agent, thromobolytic agent, immunorgulator, anti-inflammatory agent, etc., and albumin to a silicone elastomer and using the elastomer as a matrix or using a membrane of the elastomer as a drug container. n CONSTITUTION: A silicone elastomer containing ≤50wt% drug and ≤50wt% albumin is used as a matrix or a membrane of the elastomer is used as a drug container to obtain the objective slow-releasing drug preparation. The compounding of a silicone elastomer with a drug together with albumin attains the stabilization and slow releasing of the drug. Highest effect can be achieved when the drug is a polymeric drug having a molecular weight of 1,000W500,000 (e.g. peptide, protein, polysaccharide, etc.). The silicone elastomer is preferably a cold-curing elastomer such as dimethylpolysiloxane of formula (n is 100W5,000; R is CH 3 , OH or vinyl). n COPYRIGHT: (C)1987,JPO&Japio |