| abstract |
PURPOSE: Spherical particles of a polyamino acid, obtained by adding a solution of a hydrophobic polyamino acid in an organic solvent to an aqueous medium to produce a dispersion, in which the spherical particles of the polyamino acid are dispersed in the aqueous medium, and capable of controlling optionally the particle diameter. n CONSTITUTION: A hydrophobic polyamino acid, e.g. polyalanine, polyleucine or hydrophobized hydrophilic polyamino acid, etc., is dissolved in an organic solvent, preferably chloroform or dichloromethane, and the resultant solution is then added to an aqueous medium. A viscosity modifier, preferably a water-soluble polymer is preferably added thereto and the resultant mixture is stirred while evaporating the above-mentioned organic solvent to give a dispersion, in which spherical particles of the above-mentioned polyamino acid are dispersed in the above-mentioned aqueous medium. The dispersion is then filtered to give the aimed spherical particles containing the β-structure. The use of an additive for giving a porous structure provides the aimed porous spherical particles having the pore diameter corresponding to 10 2 W10 5 expressed in terms of the molecular weight of a water-soluble polysaccharide and 10W70% porosity. n COPYRIGHT: (C)1987,JPO&Japio |