http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S62164693-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d01a44763ca6b93334e8a729d66cfb72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cfc033f059d282fcd915bc8be2ae53f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-10 |
| filingDate | 1986-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_091161c4789de22f68396ecd659a7dd2 |
| publicationDate | 1987-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S62164693-A |
| titleOfInvention | Tripeptide |
| abstract | NEW MATERIAL:A compound shown by formula I (R is group shown by formula II or -Gly-NH 2 ). n EXAMPLE: A compound shown by formula III. n USE: An analgesic, stronger than morphine hydrochloride, etc., showing prolonged analgesic activity, having low toxicity and low dependence and showing im proved activity even by oral administration. n PREPARATION: For example, Boc-Phe-ONSu (Boc is t-butoxycarbonyl; ONSu is N-hydroxysuccinimide ester) is condensed with H-βAla-OBzl.Tos (Tos is tosyl) in the presence of triethylamine, etc., in a solvent such as DMF, etc., to give a compound shown by formula IV, which is treated with a solution of hydrochloric acid-dioxane to remove a protecting group Boc. Then, the com pound is successively condensed with Boc-D-Arg(NO 2 )-OH and Boc-Tyr-OH by the same method to give a compound shown by formula V, which is decom posed with an acid such as trifluoroacetic acid, etc., in the presence of a cationic scavenger such as anisole, etc., and deprotected to give a compound as exempli fied. n COPYRIGHT: (C)1987,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0113938-A1 |
| priorityDate | 1986-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.