| abstract |
NEW MATERIAL:The compound of formula I (the ring containing A is benzene ring, cyclohexane ring or indole ring; R 1 and R 2 are H, lower alkyl, phenyl, carboxyl, etc.; R 3 is N-substituted-3-aminopropionic acid, etc.; X is O or S) and its salt. n EXAMPLE: (3S)-2-[N-methyl-N-(2-carboxyethyl)-thiocarbamoyl]-1,2-,3-,4-tetrahydro-isoquinoline-3-carboxylic acid calcium salt. n USE: Hypotensor. n PREPARATION: The compound of formula I can be produced by reacting the compound of formula II with diphosgene of formula Cl 3 COC(=O)Cl in a proper solvent in the presence of a tertiary amine base at -20W-50°C, and reacting the resultant compound of formula III with the compound of formula HR 3 at room temperature. n COPYRIGHT: (C)1987,JPO&Japio |