| abstract |
PURPOSE: To provide an easily producible water-based bile acid agent for internal use, which is an easily drinkable clear liquid having masked intrinsic bitter taste of bile acid and useful as a cholagogue, by compounding a specific amount of dextrin to bile acid. n CONSTITUTION: The objective water-based bile acid agent for internal use can be produced by compounding a dextrin (e.g. amylodextrin, erythrodextrin, etc.) to a bile acid (e.g. ursodeoxycholic acid, chenodeoxycholic acid, etc.). The weight ratio of dextrin to bile acid is ≥ 30 and the concentration of dextrin in the agent is ≤ 35% (W/W). It can be prepared either by fluidized layer granulation method or dispersion method. The hazard of bile acid scattering is suppressed compared with the conventional process for preparation of a water-based agent using a bile acid cllathrate compound. A clear agent free from bitter taste can be produced with simple procedure. The nature of dextrin is weakly acidic and, accordingly, the requirement of a water-based internal agent can be satisfied without pH adjustment. n COPYRIGHT: (C)1987,JPO&Japio |