| abstract |
PURPOSE:The titled preparation that contains, as an active ingredient, a pyrazolone derivative or its salt, thus being used as a good preventive or remedy for a variety of ischemic diseases or other diseases caused by them, e.g., cerebral infarction or hemorrhage and other cerebrovascular diseases or cerebral hy pofunction caused by them. CONSTITUTION:The objective preparation contains, as an active ingredient, a pyrazolone derivative of formula I (R1 is H, aryl, 1-5C alkyl, 3-6C alkoxycarbonylalkyl; R2 is H, aryloxy, arylmercapto, 1-5C alkyl; or R1 and R2 incorporate to form 3-5C alkylene; R3 is residue of heterocyclic ring) or its pharmaceutically permissible salt. It is applied orally, intravenously or rectally. The active ingredient of formula I is synthesized by reaction of a beta-ketoacid derivative of formula II (R' is 1-5C alkyl) with a hydrazine derivative of formula III. |