| abstract |
NEW MATERIAL:3-Oxoisocarbacycline compound of formula I [R 1 is H, phenyl, 3W10C cycloalkyl, phenyl (1W2C) alkyl or one equivalent of cation; R 2 and R 3 are H, tri (1W7C) hydrocarbon-silyl or a group forming acetal bond together with O of hydroxyl group; R 4 is H, 1W10C alkyl, vinyl or ethynyl; R 5 is 1W10C alkyl, 2W10C alkenyl, 2W10C alkyl, 3W10C cycloalkyl, phenyl, phenoxy, etc.]. n EXAMPLE: 15-Deoxy-16-hydroxy-9(O)-methano-Δ 6(9α) -3-oxaprost-aglandin I 1 . n USE: A drug having prostaglandin-like activity and especially activities to protect cells and suppress the secretion of gastic acid. n PREPARATION: The compound of formula I can be produced by reacting the compound of formula II [R 21 and R 31 are tri (1W7C) hydrocarbonsilyl, etc.] with the compound of formula III (X is Cl, etc.; R 11 is H, etc.). n COPYRIGHT: (C)1987,JPO&Japio |