| abstract |
PURPOSE: To readily and effectively obtain the titled compound useful as a key intermediate for medicines, e.g. antitumor agent, etc., by bringing an allyl α-substituted methyl β-ketocarboxylate into contact with a platinum group metal salt in the presence of an inert organic medium. n CONSTITUTION: A compound expressed by formula I [R 1 and R 2 are 1W10C (substituted) hydrocarbon group or together link to form a ring; R 3 is 2W10C acyl or 1W10C sulfonyl; R 4 WR 8 are H, 1W10C hydrocarbon group or aromatic hydrocarbon group] is brought into contact with a platinum group metal or complex, e.g. phosphine of palladium or phosphite complex, in the presence of an inert organic medium, preferably THF or acetonitrile, at -78°C W the boiling point of the solvent used, preferably 0°C W room temperature to afford the aimed compound expressed by formula II. The amount of the platinum group metal salt or complex to be used is preferably 0.001W30mol%, particularly 0.1W10mol% based on the compound expressed by formula I. n COPYRIGHT: (C)1987,JPO&Japio |