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filingDate 1985-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc73a53703b5cdb6582ae13ea7614f2c
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publicationDate 1987-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S62103061-A
titleOfInvention Production of 16-substituted prostaglandin e
abstract PURPOSE: To obtain the titled compound useful as pharmaceuticals from an easily available raw material in short steps and high yield, by selectively reducing the 7,8-double bond of a 16-substituted-Δ 7 -prostaglandin E compound. n CONSTITUTION: The objective compound of formula II can be produced by selectively reducing the 7,8-double bond of a 16-substituted-Δ 7 -prostaglandin E compound with a hydrogenated organotin compound (e.g. tributyltin hydride) at 0W200°C. The starting prostaglandin E compound is a compound of formula I [R 1 is COOR 2 , CH 2 OR 3 or COCH 2 OR 3 (R 2 is H, 1W10C alkyl, phenyl, etc.; R 3 is H, tri(1W7C hydrocarbon)silyl, etc.); R 4 and R 5 are H, tri(1W7C hydrocarbon)silyl, etc.; R 6 is H, 1W4C alkyl or vinyl; R 7 is (O-containing) 3W6C alkyl, alkenyl, phenyl, etc.; Y is CH 2 X or XCH 2 (X is ethylene, cis- or trans- vinylene, etc.)], its enantiomer or their mixture at arbitrary ratio. n COPYRIGHT: (C)1987,JPO&Japio
priorityDate 1985-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 32.