| abstract |
PURPOSE: To provide the titled drug containing a 2-substituted adenosine-3',5'- cyclic phosphoric acid or its salt. n CONSTITUTION: A preventive and remedy for disseminated intravascular coagulation (DIC) can be prepared by using the compound of formula (X is Cl or Br) or its salt as a component. The agent can be administered orally or parenterally, in the form of tablet, capsule, powder, granule, troche, suppository, etc., or of injection, suspended injection, etc. Dose: 5W400mg daily in 2W4 divided doses. The compound of formula can be prepared by (1) directly dehydrating 2-chloro- or bromo-adenosine-5'-phosphate to effect the 3',5'-cyclization of the phosphoric acid part (using dicyclohexylcarbodiimide, etc. as a dehydration agent), (2) converting the product to the active ester at the phosphono group, and (3) removing the ester group with a base. n COPYRIGHT: (C)1986,JPO&Japio |