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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-06
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filingDate 1984-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fbcb825434a316e7a97f8ed630953f0
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publicationDate 1986-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S6163675-A
titleOfInvention Novel lactone compound and its synthesis
abstract NEW MATERIAL:The lactone compound of formula I (Me is methyl). n USE: Useful for the synthesis of a fragment compound corresponding to the 3W10C part of ionophore antibiotic substance, boromycin and aplasmomycin which are natural physiologically active substances having antibacterial activity. n PREPARATION: The compound of formula I can be prepared by (1) oxidizing the compound of formula II to an aldehyde compound, (2) reacting the aldehyde with lithium diisopropylamide and the compound of formula III, (3) treating the obtained compound of formula IV with an acid to afford the compound of formula V, (4) reacting the product successively with tert-butyldiphenylsilyl chloride, vinyl ethyl ether, and orthoformic acid ester, (5) reacting the resultant compound of formula VI with propanedithiol in the presence of a Lewis acid, and then with 2,2-dimethoxypropane, (6) removing the dithiol group, (7) methylating the product, and finally (8) treating with an alcoholate. n COPYRIGHT: (C)1986,JPO&Japio
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priorityDate 1984-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 38.