| abstract |
NEW MATERIAL:A compound shown by the formula I [X is 1W4C alkyl- substituted)cyclohexylene; Y is -CH 2 -, or carbonyl; n is 0 or 1] and its adduct at the saccharide part. n EXAMPLE: N-(Adenosin-6-yl)-1,3,3-rimethyl-6-azabicyclo[3,2,1]oct-an-7-one. n USE: A hypotensor. n PREPARATION: A 6-halogenoinosine shown by the formula II (A is halogen) is reacted with an alicyclic secondary amine (e.g., 3-azabicyclo[3,2,2]nonane, etc.) shown by the formula III (Y is -CH 2 -) preferably in a polar high-boiling solvent such as methyl Cellosolve, etc. by the use of triethylamine, etc. as a catalyst, and, if necessary, the prepared reaction product is converted into an adduct at the saccharide part. n COPYRIGHT: (C)1986,JPO&Japio |