| abstract |
NEW MATERIAL:The compound of formula I (R 1 and R 3 are alkanoyl and R 2 is aralkyl, or R 1 WR 3 are ≥3C alkanoyl, or R 1 and R 3 are alkanoyl and R 2 is H, or R 1 and R 3 are H and R 2 is alkanoyl, benzoyl, aryl, etc.) and its salt. n EXAMPLE: N 1 ,N 4 ,N 8 -tris(heptanoyl)spermidine. n USE: An anti-inflammatory agent. n PREPARATION: A compound of formula I wherein R 1 WR 3 are alkanoyl can be prepared by reacting the compound of formula II with an alkanoylation agent (e.g. acid anhydride, acid chloride, etc.). Another compound of formula I wherein 1 or 2 groups of R 1 WR 3 are alkanoyl can be produced by the alkanoylation of a spermidine derivative wherein 1 or 2H atoms of N 1 , N 4 and N 8 are substituted with other substituent groups. n COPYRIGHT: (C)1986,JPO&Japio |