| abstract |
NEW MATERIAL:A compound expressed by the formula (R represents acyl, alkyl, aralkyl, sulfone or carbamoyl). n EXAMPLE: 3-Palmitoylamino-4-(2-methoxyphenoxy)-benzoic acid. n USE: An antiarterioscherosis, having serum-lipid-decreasing action and action increasing prostaglandins 1 2 (PG1 2 ) production of a blood vessel wall. n PREPARATION: Ethyl 3-amino-4-(2-methoxyphenoxy)benzoate is reacted with an acylating agent, an alkylating agent, a sulfonating agent or an alkylisocyanate in a solvent such as methylene chloride to obtain 3-(N-substituted amino)-4-(2- methoxyphenoxy)benzoic acid ester. Then, the resultant product is hydrolized without isolating the ester compound to obtain the compound expressed by the formula. n COPYRIGHT: (C)1986,JPO&Japio |