| abstract |
NEW MATERIAL:The compound of formula I [R 1 is OH, group of formulaII(R 4 is H or alkanoyl; R 5 is H or alkyl), alkanoyloxy, etc.: R 2 is hydroxymethyl, formyl, etc.; R 1 and R 2 may together form the group of formula III (R 7 and R 8 are R 5 ); R 3 is OH, oxo, hydroxyimino, sulfoxy, phosphonoxy, group of formula II, etc.] and its salt. n EXAMPLE: [Olean-12-ene-22,23(4β)-dioxo-3β-yl]-β-D-glucopyranoside uronic acid. n USE: It has excellent anticomplimentary activity and blood platelet coagulation suppressing activity, and is useful as a preventive and remedy for immune diseases or autoimmune diseases such as nephritis, rheumatoid, systemic lupus erythematous, etc., and thrombosis. n PREPARATION: The compound of formula I can be prepared e.g. by reacting the compound of formula IV with the compound of formula V (R 4 ' is alkanoyl; R 5 ' is alkyl), and reacting the product with the compound of formula (R 6 ) 2 O or R 6 × (R 6 is alkanoyl). n COPYRIGHT: (C)1986,JPO&Japio |