| abstract |
PURPOSE: The titled carcinostatic substance having high affinity for CEA-forming cancer, showing no affinity for normal cells at all, consisting of a reaction product of an anti-human CEA monoclonal antibody and neocarzinostatin. n CONSTITUTION: A chemical reaction product of an anti-human CEA monoclonal antibody (e.g., anti-human colon cancer monoclonal antibody) and neocarzinostatin (NCS for short). NCS is a compound wherein a chromophore having about 700 molecular weight is bonded to an acidic protein having about 10,700 molecular weight consisting of 109 amino acid, shows strong carcinostatic action, but has side effect to have actions on normal cell simultaneously. Bonding of the monoclonal antibody having selective affinity for CEA-forming cancer to it provides the selective carcinostatic substance having high selectivity only for cancerous cells, longer durability in blood than NCS, and lower toxicity. Colon cancer, stomach cancer, etc. may be cited as the human CEA-forming cancer. n COPYRIGHT: (C)1986,JPO&Japio |