| abstract |
PURPOSE: A base composition for external preparation, capable of raising percutaneous absorption, containing a sesquiterpene alcohol compound and a specific polar compound. n CONSTITUTION: (A) 1W80wt% based on total amounts of both compounds of one or more sesquiterpene alcohol compounds, especially bisabolol, farnesol, nerolidol, santalol or vetivenol is blended with (B) one or more polar compounds selected from a group consisting of a lower alcohol, glycerin, glycerin ester, thioglycerol, lactic acid, lactic ester, alkylene glycol, mono- W diethylene glycol monoalkyl ether, lactone, and compounds shown by the formula I Wformula IV(R 1 WR 10 are H, lower alkyl; R 6 WR 9 are further NO 2 , or 1W2C acyl; n is 3W5), to give a base composition for external preparation, capable of improving percutaneous absorption of a drug, especially one having ≤1,000mol.wt. n COPYRIGHT: (C)1986,JPO&Japio |