http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S61289899-A

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filingDate 1985-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1986-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S61289899-A
titleOfInvention Production of optically active 2-halo-1-phenyl-ethanol and ester thereof
abstract PURPOSE: To obtain the titled phenylethanol and ester useful as a synthetic raw material of pharmaceuticals, agricultural chemicals, perfumes, etc., economically on an industrial scale, by treating a specific compound with an enzyme having the activity of asymmetric hydrolysis esterase. n CONSTITUTION: A 0.1W50W/V% aqueous suspension of a fatty acid ester of (R,S)-2-halo-1-phenylethanol (A) of formula I (X is halogen; R is 1W7C aliphatic hydrocarbon group) is added with 1W1/500pts. (based on 1pt. of the component A), and subjected to the asymmetric hydrolysis reaction at 10W45°C and 4.0W8.0pH under stirring to produce (S)-2-halo-1-phenylethanol (B) of formula II (X is halogen) and a fatty acid ester of (R)-2-halo-1-phenyl-ethanol (C) of formula III (X and R are same as above). The component B and the component C are separated from the reaction product by the extraction with an organic solvent and the chromatographic treatment to obtain an optically active 2-halo-1- phenylethanol and its ester. n COPYRIGHT: (C)1986,JPO&Japio
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priorityDate 1985-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 28.