| abstract |
NEW MATERIAL:The optically active (1S,5R)-7,7-alkylenedioxy-2-alkoxycarbonyl- bicyclo[3,3,0]octan-3-one of formula I [R is lower alkyl; B is (alkyl-substituted) alkylene]. n EXAMPLE: (1S,5R)-7,7-ethylenedioxy-2-ethoxycarbonylbicyclo[3,3,0]octan-3-one. n USE: Intermediate for pharmaceuticals such as platelet coagulation inhibitor, vasodilator, etc. n PREPARATION: The racemic (1SR,5RS)-7,7-alkylenedioxy-2-alkoxycarbonyl- cisbicyclo[3,3,0]octan-3-one of formula II is treated with a micro-organism capable of specifically reducing the keto group of the (1R,5S)-isomer. The objective compound of formula I is obtained as the non-reduced material. n COPYRIGHT: (C)1986,JPO&Japio |