| abstract |
NEW MATERIAL:A compound shown by the formula I (R 1 and R 2 are H or acyl; R 3 and R 4 are H or lower alkyl). n EXAMPLE: 1',3'-Dideoxy-1'-methylphosphono-β-D-fructofuranosylu-racil shown by the formula II. n USE: An inhibitor against biosynthesis of nucleic acid, useful as a carcinostatic agent and an antiviral agent. n PREPARATION: An aldehyde shown by the formula III or formula IV (A is OH-protecting group; R 5 is lower alkyl) or an aldehyde equivalent compound is reacted with a dialkyl phosphite shown by the formula V (R 6 is lower alkyl) in the presence of a base. Then, the OH group of a saccharide at 1'-position is converted into an active thioester, reduced, and deprotected, or converted into the active thioester, reduced, deprotected, dealkylated or converted into the active thioester, reduced, deprotected and further acylated. n COPYRIGHT: (C)1986,JPO&Japio |