| abstract |
NEW MATERIAL:A peptide expressed by formula I [R 1 CO- is aliphatic acyl, aromatic acyl, aromatic aliphatic acyl, etc.; R 2 is lower alkyl, lower cycloalkyl, aralkyl, etc.; R 3 is isobutyl or sec-butyl; X is formula II (R 4 is carboxyl, carbamoyl, etc.; A is single bond or alkylene; Y is OH, mercapto, etc.), etc.] and a salt thereof. E X A M P L E : N -Benzyloxycarbonyl-3-(1-naphthyl)-L-alanyl-L-leucyl-(-3S,4S)-4-amino-3-hydroxyl-6-methylheptanoic acid S-(-)-2-methylbutyramide. n USE: Useful as a diagnostic and treating agent for hypertension based on renin-angiotensin system having inhibitory action on resin. n PREPARATION: A carboxylic acid expressed by formula III or a derivative thereof is reacted wtih a compound expressed by formula IV (X 1 is a group in which Y held by X is OH, mercapto group, etc.) to give a compound in the form of an alcohol or thioalcohol in formula I. n COPYRIGHT: (C)1986,JPO&Japio |