| abstract |
PURPOSE:To provide the titled agent containing a specific monoalkylphosphoric acid ester and an active drug component, giving high transcutaneous absorbability of the drug component, exhibiting mild action to the skin and mucosa and having high safety. CONSTITUTION:The objective agent contains (A) the compound of formula I [R1 and R2 are alkyl and the total carbon number of the branched alkyl (formula II) is 8-40; X1 and X2 are H, alkali metal, ammonium, mono, di or trialkanol (2-3C) ammonium, mono, di, tri or tetraalkyl (1-4C) ammonium, basic amino acid or morpholine salt] and (B) an active drug component which can be administered by transcutaneous or transumucous absorption. The amount of the compound A is preferably 0.5-30 wt%, especially 1-20 wt% based on the whole agent. EFFECT:A sufficient effect can be attained at a low concentration of the drug component compared with conventional method, and accordingly, the side effect of the drug can be mitigated. |