| abstract |
NEW MATERIAL:A compound shown by the formula I [R 1 is amino; R 2 is H, salt-forming cation, or protecting group; R 3 is H, halogen, lower alkylthio, lower alkoxy, vinyl, -CH 2 Y (Y is H, halogen, acyloxy, heterocyclic thio, or piridinio)]. n EXAMPLE: A compound shown by the formula II. n USE: A β-lactam antimicrobial agent. n PREPARATION: For example, a compound shown by the formula III is reacted with a compound shown by the formula IV in a solvent in the presence of preferably a condensation agent (e.g., N,N'-dicyclo-hexylcarbodiimide, etc.) and, if necessary, a base (e.g., alkali metal hydrogencarbonate, etc.). n COPYRIGHT: (C)1986,JPO&Japio |