| abstract |
NEW MATERIAL:A salt of biguanide derivative 5-membered ring heterocyclic carboxylate of formula I (one or R 1 and R 2 is H, lower alkyl aralkyl, the other is lower alkyl, aralkyl). n EXAMPLE: 1,1-Dimethylbiguanide 3-methylpyrazole-5-carboxylate. n USE: It is used as a remedy for diabetes, since it has action to reduction of blood sugar and free fatty acids. It is advantageous that the efficacy is not decreased, even after it has been continuously administered and is low in toxicity. n PREPARATION: Preferably, equimolar amounts of a compound of formula IIsuch as dimethylbiguanide and another compound of formula III (e.g., 3-methylpyrazole-5-carboxylic acid) are used to effect their reaction in a solvent such as methanol or acetone at room temperature to 100°C to give a compound of formula I. The compound of formula I is isolated by the isolation process such as distillation or chromatography. n COPYRIGHT: (C)1986,JPO&Japio |