http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S61215384-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44c713790ce00813da2e6c6d57a29456 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-92 |
| filingDate | 1985-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_757006083437dd25212ad5d4b229b1c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e59fdd6e0c76967e87b2d6362e3a7463 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56fda021045e52a1c8dfefccddb88bd4 |
| publicationDate | 1986-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S61215384-A |
| titleOfInvention | Production of deoxypodophyllotoxin intermediate |
| abstract | PURPOSE: To obtain the titled compound useful as a stereoselective synthetic raw material for a compound suitable as an anticancer only by heating under reflux advantageously, by reacting a specific compound such as an easily obtainable o-hydroxymethylbenzylsilane compound as a raw material with maleic anhydride. n CONSTITUTION: A compound (e.g., o-hydroxymethylbenzylsilane compound) shown by the formula I (R is lower alkyl; X and Y are lower alkyl, or X and Y are bonded to form lower alkylene; Ar is 3,4,5-trimethoxyphenyl, 3,4- dimethoxyphenyl, etc., with the proviso that X and Y are lower alkyl when Ar is 3,4-methylenedioxyphenyl) is reacted with maleic anhydride in a solvent (preferably benzene) under reflux, to give a compound shown by the formula II. The compound shown by the formula I is obtained by reducing piperonal with sodium borohydride and from synthesis through several processes such as a reaction with thionyl chloride, etc. n COPYRIGHT: (C)1986,JPO&Japio |
| priorityDate | 1985-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.